At the forefront of advanced fertility research

Supporting women facing miscarriage and IVF implantation challenges

About EACH

At Endometrial Assessment for Conception and Health (EACH), we are at the forefront of advanced fertility research, dedicated to supporting women facing miscarriage and IVF implantation challenges. Led by Professor Jan Brosens and a dedicated team at the University of Warwick, we are committed to uncovering the causes behind implantation failure and pregnancy loss.

Through our novel diagnostic testing—Digital Endometrial Function Test (dEFT)—we provide personalized solutions to fertility challenges. Our mission is to empower women by utilising innovative research and sound scientific understanding to develop personalised treatment plans curated for each individual’s unique needs.

The problem

Many couples experience repeated IVF challenges or miscarriages struggle to find clear answers about the underlying causes and why their treatments are not succeeding. While most fertility treatments focus on egg quality and embryo selection, they often overlook a critical factor: the womb lining (the endometrium).

For a pregnancy to succeed, the endometrium must be properly prepared in each cycle—not only to support embryo implantation but also to transition into a tissue capable of sustaining the pregnancy throughout 9 months. If the endometrium isn’t optimized, the embryo will fail to implant, or the pregnancy may not progress.

Without comprehensive testing, many couples endure multiple failed treatments, still unaware of the underlying issue that is preventing a successful pregnancy.

Our solution

The Digital Endometrial Function Test (dEFT) is a breakthrough diagnostic designed to identifies issues within the womb lining, which can contribute to implantation failure or miscarriage. Every menstrual cycle is unique. The womb lining sheds and regenerates with each cycle, yet its ability to support implantation and sustain pregnancy can vary significantly. Contrary to common assumptions, the endometrium is not a passive tissue—it plays an active role in creating the right conditions for embryo implantation and early pregnancy development. The dEFT assesses the conditions in the womb lining by analysing key biological markers and provides scientific insights into this critical environment.

The dEFT provides critical insights into:

Whether the womb lining is optimally prepared for pregnancy.
Whether reproductive challenges stem from the uterine environment rather than the embryo.
How to tailor personalized treatments for improved patient care.

The science

The dEFT provides a sophisticated and comprehensive assessment of endometrial health, which is essential for a successful pregnancy. By delivering a detailed, high-resolution analysis of the endometrium, dEFT offers unprecedented insights into the factors influencing implantation. Here’s a breakdown of its four core modules:

1. Assessing Womb Lining Readiness

A successful pregnancy depends on the womb lining (endometrium) being in the optimal state for embryo implantation.

The dEFT measures whether the lining is:
- Too fragile, increasing the risk of miscarriage
- Too resistant, making implantation difficult
- Well-balanced, providing the ideal environment for pregnancy
This assessment is based on a reference range generated from over 1,500 samples, offering precise insights. Since the womb lining changes daily, results are adjusted according to the day of the cycle when the biopsy was taken, enabling personalized recommendations tailored to each patient’s unique cycle.

2. Identifying the Implantation Window

Using droplet digital PCR technology and mathematical modelling, the dEFT accurately calculates the molecular time in the womb lining.

This data is then compared with the results from home ovulation tests to determine whether the preparation of the womb lining for pregnancy is:
- Normal
- Delayed
- Advanced
This accurate calculation helps doctors normalise test results specific for each patient.

3. Uterine Natural Killer (uNK) Cell Expansion

The immune system’s uNK cells play a pivotal role in pregnancy success.

There are two primary uNK cell subpopulations:
- Immune-tolerant uNK cells, which promote embryo implantation
- Cytotoxic uNK cells, which clear damaged or abnormal cells
The dEFT provides a detailed profile of these cells, assessing the immune balance within the endometrium and its potential impact on pregnancy outcomes.

4. Detecting Subclinical Infections

The dEFT employs advanced techniques to detect subtle, low-level infections in the womb that might otherwise go unnoticed.

These infections can disrupt the microenvironment necessary for successful implantation. By measuring the presence of novel biomarkers, the dEFT offers insights into infection that could affect the success of pregnancy.